The CCBC provides quality sample processing, clinical data management, and biospecimen storage for ORDRCC projects. We provide consultation and planning services to align investigator projects and aims with the optimal collections/samples. Our services are designed to offer flexibility in project costs and maximize the utility of valuable human samples.
The CCBC staff is highly proficient in the processing and storage of full range of specimen types including:
- Biofluids (serum, plasma, CSF, urine, saliva, tears, fecal specimens)
- Cells (viable PBMC, total leukocytes, urine cells, other dissociated tissue cells)
- Tissue (viable kidney biopsy, skin biopsy, synovial biopsy)
- Snap frozen tissue blocks, tissue slides, blood smears.
- Dried blood spot cards (suitable for multiple assays)
- Nucleic Acids (genomic DNA, whole blood RNA tubes, isolated RNA) Serves as CAP processing lab for samples for CAP/CLIA Clinical Sequencing
Some key things to know about the OMRF ORDRCC Biorepository:
- It received CAP-certification in 2016
- It is one of the largest non-profit/academic based -80 °C specialized freezer storage vaults for biospecimens (2500 cubic feet)
- Over 7,000 cubic feet of -20 freezer storage
- Storage for 4 degree and ambient, humidity controlled samples
- Designed for maximal sample storage integrity and protections from loss:3 levels of redundancy (dual independent refrigeration systems and LN2 backup)
- -20 °C antechamber, humidity controlled
- Logged Security access and multiple points of system temperature, humidity, door accesses monitored 24/7
- Detailed and tested multiple level continuity plans to uninterrupted system performance
- Independent liquid nitrogen suite currently with over 150,000 vials of viable cell/tissue capacity
- Space to expand over 3 fold this capacity
- Overall repository capacity for over 5 million derivatives
The CCBC also provides services for the following types of collections:
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- Repositories–NIH sponsored collections (LFRR, NIAID ACE trials, NIAMS trials (SMILE, AMP SLE/RA), NIAMS ORDRCC, NIGMS OSCTR
- Industry Clinical Trials–Industry Sponsored, Investigator Initiated Trial collections/coordination
- Focused Repositories–Oklahoma Rheumatic Disease Cohort, Multiple Sclerosis Cohort, Diabetes Cohort, Pregnancy Cohort, Osteoarthritis, Scleroderma
CCBC has successfully provided support to numerous junior investigators who required assistance with:
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- IRB applications, clinical trial design, patient recruitment, and database management.
- Access to registries with detailed demographics, clinical phenotype data, disease activity/damage, treatment responses, and outcome information.
- Access to biorepositories with high-quality, standardized, quality-controlled biospecimens.