The CCBC staff is highly proficient in the processing and storage of full range of specimen types including:
- Biofluids (serum, plasma, CSF, urine, saliva, tears, fecal specimens)
- Cells (viable PBMC, total leukocytes, urine cells, other dissociated tissue cells)
- Tissue (viable kidney biopsy, skin biopsy, synovial biopsy)
- Snap frozen tissue blocks, tissue slides, blood smears.
- Dried blood spot cards (suitable for multiple assays)
- Nucleic Acids (genomic DNA, whole blood RNA tubes, isolated RNA) Serves as CAP processing lab for samples for CAP/CLIA Clinical Sequencing
Some key things to know about the OMRF ORDRCC Biorepository:
- It received CAP-certification in 2016
- It is one of the largest non-profit/academic based -80 °C specialized freezer storage vaults for biospecimens (2500 cubic feet)
- Over 7,000 cubic feet of -20 freezer storage
- Storage for 4 degree and ambient, humidity controlled samples
- Designed for maximal sample storage integrity and protections from loss:3 levels of redundancy (dual independent refrigeration systems and LN2 backup)
- -20 °C antechamber, humidity controlled
- Logged Security access and multiple points of system temperature, humidity, door accesses monitored 24/7
- Detailed and tested multiple level continuity plans to uninterrupted system performance
- Independent liquid nitrogen suite currently with over 150,000 vials of viable cell/tissue capacity
- Space to expand over 3 fold this capacity
- Overall repository capacity for over 5 million derivatives
The CCBC also provides services for the following types of collections:
- Repositories–NIH sponsored collections (LFRR, NIAID ACE trials, NIAMS trials (SMILE, AMP SLE/RA), NIAMS ORDRCC, NIGMS OSCTR
- Industry Clinical Trials–Industry Sponsored, Investigator Initiated Trial collections/coordination
- Focused Repositories–Oklahoma Rheumatic Disease Cohort, Multiple Sclerosis Cohort, Diabetes Cohort, Pregnancy Cohort, Osteoarthritis, Scleroderma
CCBC has successfully provided support to numerous junior investigators who required assistance with:
- IRB applications, clinical trial design, patient recruitment, and database management.
- Access to registries with detailed demographics, clinical phenotype data, disease activity/damage, treatment responses, and outcome information.
- Access to biorepositories with high-quality, standardized, quality-controlled biospecimens.